Higher Acceleration/Ejection Time Ratio Predicts Impaired Outcome in Aortic Valve Stenosis

Background: Acceleration time (AT)/ejection (ET) ratio is a marker of aortic valve stenosis (AS) severity and predicts outcome in moderate-severe AS. Methods: We explored the association increased AT/ET on prognosis 1530 asymptomatic patients with presumably mild-moderate AS, normal ejection fraction, without known diabetes or cardiovascular disease. Patients were part SEAS study (Simvastatin Ezetimibe Aortic Stenosis). grouped according to optimal threshold predict death heart failure hospitalization. Low-gradient severe AS was identified as combined area ?1.0 cm 2 mean gradient <40 mm Hg. Outcome assessed Cox regression analyses, results are reported hazard 95% CI. Results: Higher significantly associated lower systolic blood pressure, left ventricular stress-corrected midwall shortening, low flow, higher mass peak jet velocity. ?0.32 provided cutoff for predicting incident hospitalization total sample. In low-gradient this >0.32. had 79% risk (hazard ratio, 1.79 [95% CI, 1.20–2.68]). >0.32 2-fold 2.15 1.22–3.77]). Conclusions: nonsevere morbidity mortality. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT00092677.